NOVEL OLIGODEOXYRIBONUCLEOTIDES INCORPORATING L-RELATED ISODEOXYNUCLEOSIDES - SOLID-PHASE SYNTHESIS, ENZYMOLOGY, AND CD STUDIES

Authors
WENZEL T NAIR V
Citation
T. Wenzel et V. Nair, NOVEL OLIGODEOXYRIBONUCLEOTIDES INCORPORATING L-RELATED ISODEOXYNUCLEOSIDES - SOLID-PHASE SYNTHESIS, ENZYMOLOGY, AND CD STUDIES, Bioorganic & medicinal chemistry letters, 7(24), 1997, pp. 3195-3198
Citations number
17
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
24
Year of publication
1997
Pages
3195 - 3198
Database
ISI
SICI code
0960-894X(1997)7:24<3195:NOILI>2.0.ZU;2-G
Abstract
The synthesis of self-complementary oligodeoxyribonucleotides incorpor ating the L-related isodeoxynucleosides, isodA, (1) and/or isodT (4) i s described. These novel oligomers exhibit high resistance towards exo nucleases, Temperature-and concentration-dependent CD spectra and ther modynamic data of the oligomers show that isodA-isodT base pairs parti cipate in duplex stabilization. (C) 1997 Elsevier Science Ltd.