3D MULTIVOXEL PROTON SPECTROSCOPY OF HUMAN BRAIN USING A HYBRID OF 8TH-ORDER HADAMARD ENCODING WITH 2D CHEMICAL-SHIFT IMAGING

Multivoxel 3D localized proton spectroscopy using a hybrid of 1D 8th-o rder transverse Hadamard spectroscopic imaging (HSI) with 2D chemical shift imaging (CSI) is demonstrated in human brain. The spatially sele ctive HSI pulse incorporates naturally into the PRESS sequence (TE = 1 35 ms), which then both excites an 8 x 8 x 6 cm parallelepiped volume of interest (VOI) and subdivides it into eight slices. The planes of t hese slices are further partitioned into 16 x 16 voxel arrays using 2D CSI to yield 8 x 8 x 8 voxels within the VOI. Simultaneous 3D coverag e yields good voxel signal-to-noise (8, 12, and 22 for choline, creati ne, and N-acetylaspartate, respectively) from these 0.75-ml voxels, in similar to 45 min. The high spatial isolation allows localization to within less than 1 cm from the skull without fat contamination.