MINIMUM ALVEOLAR ANESTHETIC CONCENTRATIONS FOR AIRWAY OCCLUSION IN CATS - A NEW CONCEPT OF MINIMUM ALVEOLAR ANESTHETIC CONCENTRATION AIRWAYOCCLUSION RESPONSE
T. Ide et al., MINIMUM ALVEOLAR ANESTHETIC CONCENTRATIONS FOR AIRWAY OCCLUSION IN CATS - A NEW CONCEPT OF MINIMUM ALVEOLAR ANESTHETIC CONCENTRATION AIRWAYOCCLUSION RESPONSE, Anesthesia and analgesia, 86(1), 1998, pp. 191-197
Minimum alveolar anesthetic concentration (MAC) is defined as an end-t
idal concentration of inhaled anesthetic required to prevent purposefu
l movement (positive motor response) in 50% of subjects to somatic nox
ious stimuli. Although MAC for visceral noxious stimuli has not been w
ell investigated, airway occlusion can be a noxious respiratory stimul
us that can induce a visceral sensation of choking. In this study, MAC
for airway occlusion (MAC-AOR) was determined during halothane, isofl
urane, and sevoflurane anesthesia and compared with the MAC values for
somatic noxious stimuli such as toe pinch (MAC-pinch) or tetanic stim
ulus (MAC-tetanus) in cats. Thirty-few adult cats were used. In 24 cat
s, the motor responses to three different stimuli (toe pinch, tetanic
stimulus, and airway occlusion for 6 min) were observed during inhaled
anesthesia and rated as positive or negative. The concentration of an
inhaled anesthetic was changed in steps of 0.1%-0.2 vol% until the br
acketing procedure (i.e., the highest concentration of inhaled anesthe
tic permitting a positive motor response and the lowest concentration
preventing the response were determined) was completed. In 10 cats, th
e effect of anesthetic duration on MAC-AOR was also investigated. Each
mean MAC (MAC-pinch, MAC-AOR, and MAC-tetanus, respectively) was as f
ollows: halothane 0.99, 1.13, and 1.46; isoflurane 1.50, 1.65, and 2.2
2; and sevoflurane 3.07, 3.38, and 3.95. The first and last MAC-AOR va
lues determined during 6-h halothane anesthesia were 1.10 and 1.11, re
spectively. Ln conclusion, airway occlusion can be a noxious stimulus
and can induce an all-or-none type of motor response, depending on the
depth of inhalational anesthesia in cats. This phenomenon can permit
the introduction a new concept of MAC-AOR. Implications: Airway occlus
ion can be a noxious visceral stimulus and induce all-or-none type of
motor response in cats, depending on the depth of inhalational anesthe
sia. This permits the introduction of a new concept of minimum alveola
r anesthetic concentration airway occlusion response.