OBJECTIVE: To study the effects of umbilical cord insertion combinatio
ns on outcomes in monochorionic (MC) twin placentas. STUDY DESIGN: Six
ty consecutive MC placentas were analyzed by cord insertion patterns w
ith regard to growth discordance, placental parenchymal sharing, types
and patterns of inter-twin vascular anastomoses, perinatal mortality
and frequency of fetofetal transfusion. Corn insertions were classifie
d as central/eccentric (CEN) or velamentous/marginal (VEL). RESULTS: F
orty-five percent of the twins had VEL insertions. The CEN/VEL combina
tion was found in 53% of pairs. The CEN/VEL group had the highest rate
s of growth discordance > 20%, unequal placental parenchymal sharing,
uncompensated anastomoses and perinatal demise. CONCLUSION: VEL cord i
nsertion and the CEN/VEL combination are indicators of high-risk subgr
oups within MC twins. VEL cord insertions can be diagnosed by ultrasou
nd, identifying these high-risk groups.