Uncertainty is widely believed to be a central feature in illness expe
riences. Moreover, communication is thought to be essential to the con
struction, management, and resolution of uncertainty. Not surprisingly
, however, there are substantial variations in conceptions and analyse
s of this focal construct and its relation to communication. In this a
rticle, we first argue that understandings of the role of communicatio
n in health and illness can be improved substantially-thereby enhancin
g both theory development and practical applications of health communi
cation theory-by recognizing and reconciling sources of variation in c
onceptions of uncertainty and by synthesizing various specific concept
ions. We then review individual-psychological models, linguistic and d
iscourse analyses, and sociocultural and historical perspectives on un
certainty in illness. Following the review, we present a framework tha
t synthesizes many conceptions of uncertainty. We close with a discuss
ion of 5 challenges and opportunities for research and application.