A COMPLEX CONTAINING N-COR, MSIN3 AND HISTONE DEACETYLASE MEDIATES TRANSCRIPTIONAL REPRESSION

Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR, A complex has been ident ified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by tra nscription factors of the ets-domain family, These data predict that t he ligand-induced switch of heterodimeric nuclear receptors from repre ssor to activator functions involves the exchange of complexes contain ing histone deacetylases with those that have histone acetylase activi ty.