ROLE FOR N-COR AND HISTONE DEACETYLASE IN SIN3-MEDIATED TRANSCRIPTIONAL REPRESSION

Normal mammalian growth and development ave highly dependent on the re gulation of the expression and activity of the Myo family of transcrip tion factors. Mxi1-mediated inhibition of Myc activities requires inte raction with mammalian Sin3A or Sin3B proteins, which have been purpor ted to act as scaffolds for additional co-repressor factors. The ident ification of two such Sin3-associated factors, the nuclear receptor co -repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.