GLYCOSYLATED HEMOGLOBIN AND FETAL GROWTH IN NORMAL, GESTATIONAL AND INSULIN-DEPENDENT DIABETES-MELLITUS PREGNANCIES

Aims of the study were: evaluation of HbA(1)c levels ir;, the peripher al blood of pregnant women with insulin dependent diabetes, gestationa l diabetes, glucose intolerance, and healthy pregnant controls; implic ations of HbA(1)c concentration on detection and the control of women, with impaired carbohydrate metabolism in pregnancy; comparison of HbA (1)c levels with appearance of miscarriages, and premature deliveries; comparison of weight gain during pregnancy to HbA(1)c levels; compari son of difference from ideal body weight with HbA(1)c in diabetic preg nant women; comparison of neonatal birth weight and HbA(1)c levels. 29 0 pregnant women were enrolled to the study. The highest value of HbA( 1)c teas in the group IDDM pregnant women (7.7% +/- 1.8%), and the low est value of HbA(1)c was in the control group (4.1% +/- 0.5%). Statist ically significant coefficients were found between HbA(1)c and weight gain during pregnancy, between weight deviation from ideal body weight and HbA(1)c (r = 0.54 and r = 0.48 respectively); and between, newbor ns weight and HbA(1)c (r = 0.52). Well regulated glycemia and intensiv e pregnancy follow-up of diabetic women reduces stillbirths, neonatal complications and neonatal mucrosomia incidence.