RELATIONSHIP BETWEEN THE SUSCEPTIBILITY F OR SUBACUTE MYELO-OPTICO-NEUROPATHY (SMON) AND POLYMORPHISMS OF CYP2D6 AND CYP2C19

We analyzed the CYP2D6 and CYP2C19 genotypes from 5 patients with a di agnosis of subacute myelo-optico-neuropathy (SMON) after the informed consent was obtained. No homozygous poor metabolizer (PM) genotype rep orted to be associated with Parkinson's disease !PD:I was found in the present cases. The mutation located at the Hha I site of the CYP2D6 s peculated to be associated with PD was found heterozygously in only on e case. As for CYP2C19, no mutant homozygous genotype which was report ed to be associated with the low metabolism of mephenytoin was found. And a mutant mi allele was found heterozygously in two cases, and a mu tant m2 allele in the one case. There was no significant relationship between SMON and these polymorphisms of CYP2D6 and CYP2C19. These resu lts suggest that the poor metabolizer/extensive metabolizer (PM/EM) po lymorphisms of CYP2D6 and CYP2C19 may not be useful molecular markers for predicting the onset of SMON.