RECURRENT PHYLLODES TUMOR IN A MAN

The case of a 35-year-old man with a borderline-type cystosarcoma phyl lodes is presented. Four years after the primary excision of the tumor , wide excision of a local recurrence and postoperative radiotherapy w ere performed. No repeated relapse was observed during a 5-year follow -up. Neither significant endocrine changes nor genetic alteration coul d be proven. However, a slightly increased SHBG concentration was dete cted, resulting in a decreased biologically available androgen level r educed testosterone/SHBG index. This phenomenon might be a consequence of the chronic liver disease of the patient due to his type II diabet es mellitus and alcohol abuse. In addition to the conventional histopa thological examinations, immunohistochemical and electronmicroscopic i nvestigations were carried out on tissue sections, and the steroid rec eptors, EGF receptors and EGF-like activity of the tumor were also stu died.