EFFECTS OF OSTEOCHONDRAL FRAGMENTATION AND INTRAARTICULAR TRIAMCINOLONE ACETONIDE TREATMENT ON SUBCHONDRAL BONE IN THE EQUINE CARPUS

To determine the effects of osteochondral fragmentation and intra-arti cular corticosteroid treatment on dynamics of bone remodelling and fra gility, 12 horses each had a unilateral, 8 mm osteochondral fragment c reated in the distal aspect of one radiocarpal bone, Six of the horses were treated in the fragmented joint, and the other 6 were treated in the nonfragmented joint with 12 mg of triamcinolone acetonide (TA) 14 and 28 days after surgery. All horses were exercised on a high-speed treadmill starting 15 days, and ending 72 days after surgery, Horses t reated with TA in the fragmented joints were significantly less lame t han those treated in the nonfragmented joints. Third carpal bones from joints, with fragments showed significantly more vascularity, single labelled surface, total labelled surface and mineralising surface in s ubchondral and subjacent trabecular bone, Trends were also seen toward s higher vascular canal volume and osteochondral junction remodelling sites in third carpal bones from fragmented joints. No significant dif ferences were seen in microdamage density or size between fragmented a nd nonfragmented joints. No significant influence of TA treatment was seen on any parameter measured. The results from this study show that osteochondral fragmentation induces significant changes in remodelling of opposing bones, and that the administration of corticosteroids int o joints with fragmentation does not significantly alter bone remodell ing or fragility.