Objective: To document the occurrence of chronic massive knee effusion
s in patients with familiar Mediterranean fever (FMF). Patients: Three
cases of chronic massive knee effusion of young FMF patients requirin
g open synovectomy are presented. Results: Open synovectomy necessitat
ed protracted rehabilitation, eventually with good results. Conclusion
s: FMF should be considered in the differential diagnosis of chronic m
assive knee effusion. Early diagnosis and daily colchicine treatment g
enerally result in a good clinical outcome and may eliminate the need
for open synovectomy in favor of arthroscopic surgery. Copyright (C) 1
997 by W.B. Saunders Company.