TUMOR-SPECIFIC PYRUVATE-KINASE ISOENZYME M-2 INVOLVED IN BIOCHEMICAL STRATEGY OF ENERGY GENERATION IN NEOPLASTIC-CELLS

Authors
GUMINSKA M IGNACAK J KEDRYNA T STACHURSKA MB
Citation
M. Guminska et al., TUMOR-SPECIFIC PYRUVATE-KINASE ISOENZYME M-2 INVOLVED IN BIOCHEMICAL STRATEGY OF ENERGY GENERATION IN NEOPLASTIC-CELLS, Acta Biochimica Polonica, 44(4), 1997, pp. 711-724
Citations number
59
Categorie Soggetti
Biology
Journal title
Acta Biochimica Polonica → ACNP
ISSN journal
0001527X
Volume
44
Issue
4
Year of publication
1997
Pages
711 - 724
Database
ISI
SICI code
0001-527X(1997)44:4<711:TPIMII>2.0.ZU;2-C
Abstract
The differences in properties of pyruvate kinase (EC 2.1.7.40) from no rmal tissues and animal or human tumors are described and their signif icance for various metabolic abnormalities is reviewed. The tumor vari ant gamma(3) from M-2 isoenzyme of pyruvate kinase sensitive to L-cyst eine inhibition, when over-expressed, can be used as a marker of tumor igenic transformation. It seems that this variant represents a tumor-s pecific oncoprotein, involved in a novel metabolic strategy of energy generation during increased cell proliferation.