MS-681A, MS-681B, MS-681C AND MS-681D, NEW INHIBITORS OF MYOSIN LIGHT-CHAIN KINASE FROM MYROTHECIUM SP. KY6568 - I - CHARACTERIZATION OF PRODUCING STRAIN AND PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES

Authors
YANO H NAKANISHI S IKUINA Y ANDO K YOSHIDA M SAITOH Y MATSUDA Y
Citation
H. Yano et al., MS-681A, MS-681B, MS-681C AND MS-681D, NEW INHIBITORS OF MYOSIN LIGHT-CHAIN KINASE FROM MYROTHECIUM SP. KY6568 - I - CHARACTERIZATION OF PRODUCING STRAIN AND PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 50(12), 1997, pp. 992-997
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
12
Year of publication
1997
Pages
992 - 997
Database
ISI
SICI code
0021-8820(1997)50:12<992:MMMAMN>2.0.ZU;2-W
Abstract
Novel compounds MS-681a, b, c and d were isolated from the culture bro th of a fungal strain KY6568. The strain was identified as Myrothecium sp. from its morphological characteristics. MS-681a, b, c and d inhib ited the activity of purified smooth muscle myosin light chain kinase with IC50 values of 0.11, 0.29, 0.095 and 0.26 mu M, respectively. Cyc lic AMP-dependent protein kinase, cyclic GMP-dependent protein kinase and protein kinase C were not inhibited at 100 mu M by MS-681 compound s.