ROSEOCARDIN, A NOVEL CARDIOTONIC CYCLODEPSIPEPTIDE FROM TRICHOTHECIUM-ROSEUM TT103

Citation
A. Tsunoo et al., ROSEOCARDIN, A NOVEL CARDIOTONIC CYCLODEPSIPEPTIDE FROM TRICHOTHECIUM-ROSEUM TT103, Journal of antibiotics, 50(12), 1997, pp. 1007-1013
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology
Journal title
ISSN journal
00218820
Volume
50
Issue
12
Year of publication
1997
Pages
1007 - 1013
Database
ISI
SICI code
0021-8820(1997)50:12<1007:RANCCF>2.0.ZU;2-G
Abstract
A new cyclodepsipeptide, designated roseocardin, was isolated from the culture broth of Trichothecium roseum TT103. Roseotoxin B and destrux ins A and B were also isolated during the same procedure. The structur e of roseocardin was determined by EI-MS, NMR and X-ray crystallograph ic analysis. Roseocardin as well as the other cyclodepsipeptides were shown to produce positive inotropic effects on rat heart muscles.