A. Tsunoo et al., ROSEOCARDIN, A NOVEL CARDIOTONIC CYCLODEPSIPEPTIDE FROM TRICHOTHECIUM-ROSEUM TT103, Journal of antibiotics, 50(12), 1997, pp. 1007-1013
A new cyclodepsipeptide, designated roseocardin, was isolated from the
culture broth of Trichothecium roseum TT103. Roseotoxin B and destrux
ins A and B were also isolated during the same procedure. The structur
e of roseocardin was determined by EI-MS, NMR and X-ray crystallograph
ic analysis. Roseocardin as well as the other cyclodepsipeptides were
shown to produce positive inotropic effects on rat heart muscles.