THE ROLE OF QUANTITATIVE ELECTROMYOGRAPHY IN INCLUSION-BODY MYOSITIS

Objective and methods-Inclusion body myositis is said to have both myo pathic and neurogenic features on electrophysiological tests. Twenty o ne studies from 20 patients with biopsy defined inclusion body myosis, 13 of whom had quantitative electromyography (qEMG), were reviewed to determine if this technique added diagnostic specificity (one patient had both needle EMG and a later study with qEMG before muscle biopsy) . Results-Excessive numbers of polyphasic motor unit potentials (MUPs) (>12% per muscle) were seen in 11 of the 13 patients. In 10 of 13 pat ients, mean MUP duration was abnormally reduced (26% to 48%). In three patients, mean MUP duration was abnormally reduced only after polypha sic MUPs were excluded. In all 13 patients, the simple MUP duration wa s reduced. Myopathy was unequivocally diagnosed in all 13 studies that included qEMG; of the remaining eight patients, the conclusions of th e electrophysiological studies without qEMG was myopathy (one), neurog enic (four) or non-diagnostic (three). Conclusions-There is no evidenc e of a neurogenic component in inclusion body myosis if qEMG is used. Quantitative EMG is often necessary to make an electrophysiological di agnosis of a myogenic disorder in patients with inclusion body myosis.