H. Ahissou et al., EVOLUTION OF GRASS-CUTTER (THRYONOMYS SWINDERIANUS) INFLAMMATION MARKERS - COMPARISON WITH RABBIT (ORYCTOLAGUS-CUNICULUS) AND RAT (RATTUS-NORVEGICUS), Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 118(4), 1997, pp. 1309-1312
An inflammatory reaction was induced in grass-cutters (Thryonomys swin
derianus) by injecting turpentine. The changes in the plasma haptoglob
in, fibrinogen, alpha(2) macroglobulin and immunoglobulin G was follow
ed for 23 days by immunonephelometry. The results were compared to rat
and rabbit. They showed that (a) the inflammatory reaction is delayed
in the grass-cutter compared to rats and rabbits; (b) the concentrati
on of haptoglobin increases less than in rat and rabbit; (c) the fibri
nogen concentration is very low in the grass-cutter, despite hypercoag
ulability of blood; (d) the changes in the plasma alpha(2)-macroglobul
in in the grass-cutter seems to be comparable to that of rabbit alpha(
1) macroglobulin in amplitude and in its slow return to the initial co
ncentration; and (e) fibrinogen and haptoglobin are suitable markers f
or grass-cutter inflammation monitoring. (C) 1997 Elsevier Science Inc
.