OBJECTIVES. This study attempts to develop a comprehensive set of como
rbidity measures for use with large administrative inpatient datasets.
METHODS. The study involved clinical and empirical review of comorbid
ity measures, development of a framework that attempts to segregate co
morbidities from other aspects of the patient's condition, development
of a comorbidity algorithm, and testing on heterogeneous and homogene
ous patient groups. Data were drawn from all adult, nonmaternal inpati
ents from 438 acute care hospitals in California in 1992 (n = 1,779,16
7). Outcome measures were those commonly available in administrative d
ata: length of stay, hospital charges, and in-hospital death. RESULTS.
A comprehensive set of 30 comorbidity measures was developed. The com
orbidities were associated with substantial increases in length of sta
y, hospital charges, and mortality both for heterogeneous and homogene
ous disease groups. Several comorbidities are described that are impor
tant predictors of outcomes, yet commonly are not measured. These incl
ude mental disorders, drug and alcohol abuse, obesity, coagulopathy, w
eight loss, and fluid and electrolyte disorders. CONCLUSIONS. The como
rbidities had independent effects on outcomes and probably should not
be simplified as an index because they affect outcomes differently amo
ng different patient groups. The present method addresses some of the
limitations of previous measures. It is based on a comprehensive appro
ach to identifying comorbidities and separates them from the primary r
eason for hospitalization, resulting in an expanded set of comorbiditi
es that easily is applied without further refinement to administrative
data for a wide range of diseases.