ASSAY OF UNDERIVATIZED AZELAIC ACID IN PHARMACEUTICAL AND COSMETIC PRODUCTS BY HPLC

Authors
SCALIA S BIANCHI A VILLANI S GUARNERI M
Citation
S. Scalia et al., ASSAY OF UNDERIVATIZED AZELAIC ACID IN PHARMACEUTICAL AND COSMETIC PRODUCTS BY HPLC, Die Pharmazie, 52(12), 1997, pp. 929-931
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
52
Issue
12
Year of publication
1997
Pages
929 - 931
Database
ISI
SICI code
0031-7144(1997)52:12<929:AOUAAI>2.0.ZU;2-X
Abstract
A rapid HPLC procedure was developed for the assay of azelaic acid in pharmaceutical and cosmetic formulations without prior derivatization. After solid-phase extraction using disposable silica-based strong ani on exchange cartridges, samples were analysed directly on a LiChrosphe r RP-IX reversed-phase column with spectrophotometric detection at 210 nm and acetonitrile/phosphate buffer as eluent. The recovery of azela ic acid from the different matrices was between 93.7 and 96.9%. The me thod is simple, reproducible and selective and it is suitable for rout ine analyses of commercial products.