PERFORMANCE-CHARACTERISTICS OF COMBINED HAEMODIALYSIS HAEMOPERFUSION SYSTEM FOR REMOVAL OF BLOOD TOXINS/

The application of high clearance haemodialysis (HD) for removal of sm all molecules of waste metabolites, has been practised for many pears. Haemoperfusion (HP) is capable of effective removal of middle and pro tein-bound molecules. The combined HD/HP system is thought to give a m ore effective treatment for patients of renal failure or drug intoxica tion. This paper discusses the performance characteristics of removal of toxic substances (e.g. paraquat and creatinine), using the combined HD/HP recycled system in two different arrangements (HD-HP and HP-HD) . The results demonstrate that for most favourable adsorbing solutes, the HD-HP arrangement gives higher performance whereas, HP-HD arrangem ent is more suitable and gives more effective detoxication characteris tics for unfavourable adsorbing solutes. (C) 1997 IPEM. Published by E lsevier Science Ltd.