RELATIONSHIP BETWEEN CONFORMATION AND ANTIVIRAL ACTIVITY - IV - 5-ETHYL-2'-DEOXYURIDINE AND 5-ETHYL-2'-DEOXYCYTIDINE

Authors
STUART AL KUMAR SVP GUPTA SV ZOGHAIB WM NAPPER S BROWN KC MANNALA S DELBAERE LTJ
Citation
Al. Stuart et al., RELATIONSHIP BETWEEN CONFORMATION AND ANTIVIRAL ACTIVITY - IV - 5-ETHYL-2'-DEOXYURIDINE AND 5-ETHYL-2'-DEOXYCYTIDINE, Nucleosides & nucleotides, 16(12), 1997, pp. 2219-2231
Citations number
37
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
12
Year of publication
1997
Pages
2219 - 2231
Database
ISI
SICI code
0732-8311(1997)16:12<2219:RBCAAA>2.0.ZU;2-P
Abstract
5-Ethyl-2'-deoxyuridine (EtdUrd), though a potent inhibitor of herpes simplex virus (HSV) replication, is rapidly catabolized to produce an inactive pyrimidine base by thymidine and/or uridine phosphorylases. 5 -Ethyl-2'-deoxycytidine (EtdCyd) was synthesized to confer metabolic s tability and thus improve efficacy against systemic HSV infections. Et dCyd was inactive against HSV in the presence or absence of deaminase inhibitors in VERO cells up to 2 mM. The relationship between molecula r conformation and antiherpes activity for EtdUrd and EtdCyd is discus sed.