CLEAR-CELL SARCOMA OF THE ILEUM - THE CRUCIAL ROLE OF CYTOGENETICS FOR THE DIAGNOSIS

Authors
DONNER LR TROMPLER RA DOBIN S
Citation
Lr. Donner et al., CLEAR-CELL SARCOMA OF THE ILEUM - THE CRUCIAL ROLE OF CYTOGENETICS FOR THE DIAGNOSIS, The American journal of surgical pathology, 22(1), 1998, pp. 121-124
Citations number
18
Categorie Soggetti
Pathology,Surgery
Journal title
The American journal of surgical pathology → ACNP
ISSN journal
01475185
Volume
22
Issue
1
Year of publication
1998
Pages
121 - 124
Database
ISI
SICI code
0147-5185(1998)22:1<121:CSOTI->2.0.ZU;2-P
Abstract
We report a case of clear cell sarcoma that arose in the ileum and met astasized to the liver. The tumor cells did not contain melanin or gly cogen; expressed S-100 protein, but not HMB45; and contained possible atypical melanosomes when examined by electron microscopy. They carrie d a clonal chromosomal rearrangement: 50,XY,t(2;7)(q37;q22),+8,+8,+9,11, t(12;22)(q13;q12). The diagnosis was greatly facilitated by the cy togenetic analysis. The translocation t(12;22)(q13;q12-13) has been re ported as specific for clear cell sarcomas.