P. Vestergaard, CLOZAPINE IN TREATMENT-RESISTANT MANIA, B IPOLAR MANIC-DEPRESSIVE DISORDERS, AND TREATMENT-RESISTANT DEPRESSION, Nordic journal of psychiatry, 51, 1997, pp. 53-55
Clozapine appears to be effective and well-tolerated in the short-term
treatment of severe and treatment-resistant mood disorders, particula
rly in the manic excited and psychotic phases of schizoaffective and b
ipolar disorders. The same is probably true of maintenance treatment o
f bipolar and schizoaffective disorders, although experience with thes
e is very limited.