Tularemia was diagnosed in 2 cats that were examined because of pyrexi
a and lethargy; both cats had a history of exposure to wild rabbits. O
ne cat was vomiting, and the other was anorectic. Physical examination
revealed dehydration, lymphadenopathy, and hepatomegaly. Hematologic
and serum biochemical abnormalities included toxic neutrophils, high b
and neutrophil count, thrombocytopenia, and hyperbilirubinemia. Diagno
sis was confirmed by isolating Francisella tularensis subsp tularensis
from bone marrow or lymph node aspirates. Evaluation of samples colle
cted during the acute and convalescent phases of the disease revealed
an increase in serum F tularensis antibody titer. Both cats responded
to treatment with fluids and antibiotics.