GEFS, GAPS, GDIS AND EFFECTORS - TAKING A CLOSER (3D) LOOK AT THE REGULATION OF RAS-RELATED GTP-BINDING PROTEINS

Authors
GEYER M WITTINGHOFER A
Citation
M. Geyer et A. Wittinghofer, GEFS, GAPS, GDIS AND EFFECTORS - TAKING A CLOSER (3D) LOOK AT THE REGULATION OF RAS-RELATED GTP-BINDING PROTEINS, Current opinion in structural biology, 7(6), 1997, pp. 786-792
Citations number
54
Journal title
Current opinion in structural biology → ACNP
ISSN journal
0959440X
Volume
7
Issue
6
Year of publication
1997
Pages
786 - 792
Database
ISI
SICI code
0959-440X(1997)7:6<786:GGGAE->2.0.ZU;2-Z
Abstract
Cell biology depends on the interactions of macromolecules, such as pr otein-DNA, protein-protein or protein-nucleotide interactions. GTP-bin ding proteins are no exception to the rule. They regulate cellular pro cesses as diverse as protein biosynthesis and intracellular membrane t rafficking. Recently, a large number of genes encoding GTP-binding pro teins and the proteins that interact with these molecular switches hav e been cloned and expressed. The 3D structures of some of these have a lso been elucidated. (C) Current Biology Ltd ISSN 0959-440X.