ULTRASTRUCTURAL CRITERIA THAT PROVE THE SIMILARITIES BETWEEN AMPHIBIAN AND HUMAN TUMORS

Authors
ABDELMEGUID NE ELMOFTY MM SADEK IA ESSAWY AE ABDELALEEM EA
Citation
Ne. Abdelmeguid et al., ULTRASTRUCTURAL CRITERIA THAT PROVE THE SIMILARITIES BETWEEN AMPHIBIAN AND HUMAN TUMORS, Oncology, 54(3), 1997, pp. 258-263
Citations number
17
Categorie Soggetti
Oncology
Journal title
Oncology → ACNP
ISSN journal
00302414
Volume
54
Issue
3
Year of publication
1997
Pages
258 - 263
Database
ISI
SICI code
0030-2414(1997)54:3<258:UCTPTS>2.0.ZU;2-R
Abstract
Toads fed with 0.5 mg 7,12-dimethylbenz(a)anthracene twice a week for 12 weeks displayed liver tumors in 27 out of 100 cases. Electron micro graphs of liver tumors showed some criteria of malignancy, such as the presence of nuclear pockets, pseudoinclusions, dilatation of the cist ernae of rough endoplasmic reticulum and loss of cell junctions. These features are closely similar to those of true malignancy described in humans and other mammals.