CONCENTRATION-RESPONSE RELATIONSHIPS FOR CD, CU, AND ZN AND METALLOTHIONEIN MESSENGER-RNA INDUCTION IN LARVAE OF CRASSOSTREA-VIRGINICA

Authors
ROESIJADI G HANSEN KM UNGER ME
Citation
G. Roesijadi et al., CONCENTRATION-RESPONSE RELATIONSHIPS FOR CD, CU, AND ZN AND METALLOTHIONEIN MESSENGER-RNA INDUCTION IN LARVAE OF CRASSOSTREA-VIRGINICA, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 118(3), 1997, pp. 267-270
Citations number
21
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
13678280
Volume
118
Issue
3
Year of publication
1997
Pages
267 - 270
Database
ISI
SICI code
1367-8280(1997)118:3<267:CRFCCA>2.0.ZU;2-1
Abstract
MT mRNA concentrations in 1-week-old larvae of the oyster Crassostrea virginica exhibited thresholds for induction and linear increases with increasing exposure concentrations above the thresholds after 24 hr e xposures to Cd, Cu, or Zn. Based on the thresholds for metal induction and the slopes of the concentration-response curves, the order of sen sitivity of MT mRNA induction to these metals was Cd > Cu > Zn. When c oncentrations of metals required to induce MT mRNA were compared with the ambient metal concentrations, 73-fold, 16-fold, and 100-fold incre ases in environmental metal concentrations were needed for induction b y Cd, Cu, and Zn, respectively. (C) 1997 Elsevier Science Inc.