The ISPA (Imaging Silicon Pixel Array)-tube is a position-sensitive ph
oton detector. Originally developed for HEP applications, it can also
be envisaged for biomedical applications. By coupling it to scintillat
ing crystals or crystal arrays (YAP) we built a gamma-camera and detec
ted through a collimator the 122 keV gamma-rays from a Co-57 source. T
his paper presents the results obtained with two different ISPA-tube p
rototypes: the first ISPA-tube, having a glass fibre optic input windo
w, allows to achieve very high spatial resolutions; the second ISPA-tu
be prototype, with its non fibre optic quartz input window, leads to m
uch better energy resolutions while preserving sub-millimetric spatial
resolutions.