SOME GEIPARVARIN BIOISOSTERES AND HOMOLOGS - SYNTHESIS AND BIOLOGICALEVALUATION AGAINST HUMAN COLON-CARCINOMA CELLS (LOVO)

Authors
VALENTI P RAMPA A BISI A BELLUTI F DARE P CARRARA M CIMA L
Citation
P. Valenti et al., SOME GEIPARVARIN BIOISOSTERES AND HOMOLOGS - SYNTHESIS AND BIOLOGICALEVALUATION AGAINST HUMAN COLON-CARCINOMA CELLS (LOVO), Anti-cancer drug design, 12(2), 1997, pp. 137-144
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Oncology,Biology,"Chemistry Medicinal
Journal title
Anti-cancer drug design → ACNP
ISSN journal
02669536
Volume
12
Issue
2
Year of publication
1997
Pages
137 - 144
Database
ISI
SICI code
0266-9536(1997)12:2<137:SGBAH->2.0.ZU;2-Y
Abstract
Some geiparvarin bioisosteres and homologues are described. The compou nds were tested on LoVo cells (human colon carcinoma cell line). The E C50 values of the synthesized compounds ranged from 35.04 mu M (compou nd 3) to 11.88 mu M (compound 4), while the EC50 value of geiparvarin 1 was 13.30 mu M.