STUDY ON THE ANTIOXIDANT ACTIVITY OF CHOLESTERYL ESTERS OF SOME PHENOLIC-ACIDS BY CHEMILUMINESCENCE

Four cholesteryl esters of cinnamic acid derivatives, cholesteryl 2 '' -hydroxycinnamate, cholesteryl 3 ''-hydroxycinnamate, cholesteryl 4 '' -hydroxy-cinnamate and cholesteryl 3 '',4 ''-dihydroxycinnamate, as we ll as cholestanyl 2 '' hydroxycinnamate, which can be used as potentia l inhibitors of lipids oxidation, have been investigated for their rad ical scavenging efficiency by a chemiluminescence method. The rate con stants of inhibition (k(Inh)) were determined in a model reaction of a n initiated oxidation of tetraline at 353 K. The chemiluminescent resu lts show that the four cholesteryl esters are efficient radical accept ers, and that among them, cholesteryl 3 '',4 ''-dihydroxycinnamate is a particularly efficient radical scavengers with an inhibition rate co nstant of 1.8 x 10(5) dm(3) mol(-1) s(-1) (C) 1997 Elsevier Science S. A.