Safe levels of anticoagulation are normally considered to be achieved
if patients are maintained within their therapeutic international norm
alized ratio (INR) range for 70% or more time, but evidence in the Uni
ted Kingdom suggests that this is often not attained. Recently, altern
ative models in the management of out-patient anticoagulation have bee
n investigated with favourable results. We report on a study which com
pared a consultant anticoagulant service (CAS) with a nurse specialist
service (NSAS). A sequential design was used with data collected on t
he consultant run service (GAS), followed by similar data on a NSAS ov
er two 6 month periods. Two patient groups were recruited: those newly
referred (group A) and those on long-term treatment (group B). Outcom
es were the proportion of time patients spent within INR range, docume
ntation of relevant clinical details, number of drugs taken which may
adversely interact with and/or inhibit haemostatic function and patien
t knowledge, The results indicate that the NSAS was as good as the CAS
in maintaining therapeutic control and better at documenting relevant
clinical details in reducing the number of drugs taken which may adve
rsely interact with and/or inhibit haemostatic function and in improvi
ng some aspects of patient knowledge.