THE GENETICS OF SCHIZOPHRENIA - PAST, PRESENT, AND FUTURE CONCEPTS

Although a genetic susceptibility for schizophrenia has been long esta blished and even noted by Kraepelin in 1907, the mechanisms for its in heritance remains unknown. No candidates have proven to be correct and while many weakly positive chromosomal linkages have been reported, n one have yet been consistently replicated. The following review examin es the present status of these findings. The conclusion is that the fi eld must move on to finding a consistently replicable mutation segrega ting with schizophrenia in families, before any of the present linkage results can be resolved. (C) 1997 Elsevier Science B.V.