EXPERIMENTAL STUDIES ON THE ANTITUSSIVE PROPERTIES OF THE NEW XANTHINE DERIVATIVE 1H-PURINE-2,6-DIONE, -3-METHYL-7[(5-METHYL-1,2,4-OXADIAZOL-3-YL)METHYL] .1. IN-VIVO DEMONSTRATION OF THE EFFECTS ON ANIMAL-MODELS OF COUGH AND OF MUCOCILIARY CLEARANCE

CH-13584 (formerly: KHL-8425, 1H-purine-2,6-dione, 3-methyl-7[(5-methy l-1,2,3-oxadiazol-3-yl)methyl], CAS 115779-20-9) is a new xanthine der ivative synthesized with the purpose to develop a highly safe compound against several pulmonary disorders, especially for the treatment of acute and chronic cough. CH-13584 showed acute and chronic antitussive activity on citric acid spray-evoked cough model in guinea-pig. CH-13 584 was also effective on capsaicine spray and mechanical irritation-i nduced cough in guinea-pig and rabbit, respectively. The effectivity o f CH-13584 on antitussive tests reached and in some cases even exceede d the effectivity of the reference compounds. The compound increased t he mucociliary clearance at lower doses than bromhexine.