SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-DIALKYLAMINOMETHYL-2-(P-SUBSTITUTED PHENYL)-5-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

1-(Dialkylaminomethyl)-2-(p-substituted phenyl)-5-substituted benzimid azole derivatives 1 have been synthesized by reacting 2-phenylbenzimid azole derivatives with formaldehyde: and a secondary amine. The deriva tives of 2-phenylbenzimidazole were obtained by reacting the bisulfide addition product of substituted benzaldehydes with 4-substituted-o-ph enylenediamines. Their structures were confirmed by microanalysis, IR and NMR spectral analysis. Antimicrobial activity of the compounds was investigated by the microdilution susceptibility test in Mueller-Hint on Broth and Sabouraud Dextrose Broth was used for the determination o f antibacterial and antifungal activities Test organisms: Staphylococc us aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 as Gram-posi tive bacteria, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 as Gram-negative bacteria. and Candida albicans, C. parapsi losis, C. stellatoidea as yeast-like fungi. Compounds 1a, 1b; 1c, 1e a nd 1i showed slight to moderate activity against all microorganisms. C ompound 1g showed the highest activity. It was found more potent than streptomycin against Enterococcus faecalis and Pseudomonas aeruginosa.