ELECTRON-TOPOLOGICAL INVESTIGATION OF THE STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF THIOSEMICARBAZONE DERIVATIVES

Citation
As. Dimoglo et al., ELECTRON-TOPOLOGICAL INVESTIGATION OF THE STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF THIOSEMICARBAZONE DERIVATIVES, Arzneimittel-Forschung, 47(4), 1997, pp. 415-419
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00044172
Volume
47
Issue
4
Year of publication
1997
Pages
415 - 419
Database
ISI
SICI code
0004-4172(1997)47:4<415:EIOTSA>2.0.ZU;2-K
Abstract
In the frameworks of the electron-topological method (ETM) the structu re-antitumor activity relationship was investigated for a series of th iosemicarbazone derivatives. The series included 70 compounds. Conform ational analysis and quantum-chemical calculations were carried out fo r each compound. The revealed activity feature showed a satisfactory d escription of the class of active compounds according to two different parameters P and alpha estimating the probabilities of the feature re alization in the class of active compounds (they are equal to 0.94 and 0.86, correspondingly). The results of testing demonstrated the high ability of ETM in predicting the activity investigated.