SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF MONOCYCLIC BETA-LACTAMS RELATED TO CEPHALOSPORIN AND PENICILLIN SULFONES

Authors
MARCHANDBRYNAERT J
Citation
J. Marchandbrynaert, SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF MONOCYCLIC BETA-LACTAMS RELATED TO CEPHALOSPORIN AND PENICILLIN SULFONES, Bulletin des Societes chimiques belges, 106(9-10), 1997, pp. 585-604
Citations number
33
Categorie Soggetti
Chemistry
Journal title
Bulletin des Societes chimiques belges → ACNP
ISSN journal
00379646
Volume
106
Issue
9-10
Year of publication
1997
Pages
585 - 604
Database
ISI
SICI code
0037-9646(1997)106:9-10<585:SAAAOM>2.0.ZU;2-S
Abstract
Starting from the natural Penicillins G and V, a series of monocyclic p-lactams B were prepared, functionalized at N(1) by an acetyl residue and at C(3) and C(4), respectively, by an acylamino side-chain and a sulfone substituent in a cis-stereochemical relationship. The TAL and PIV prodrugs exhibited weak antibacterial activity in vitro.