SUCCESSFUL TREATMENT OF SEVERE REFRACTORY IDIOPATHIC THROMBOCYTOPENICPURPURA WITH LIPOSOMAL DOXORUBICIN

Idiopathic thrombocytopenic purpura (ITP) is refractory to initial tre atment (steroids and splenectomy) in 25 to 30% of patients, These pati ents have a significant risk of fatal hemorrhage, Two patients with IT P refractory to multiple interventions and severe depression of platel et counts responded to treatment with liposomal doxorubicin with a ret urn of platelet counts to normal, The drug is easily administered and was well tolerated, Use of this drug in refractory ITP merits further study. (C) 1998 Wiley-Liss, Inc.