SUCCESSFUL TREATMENT OF ACQUIRED FACTOR-VIII INHIBITORS WITH CYCLOSPORINE

The treatment of Factor VIII inhibitors remains controversial and no s tandard therapy exists, We describe in this report two consecutive pat ients with this inhibitor that responded to cyclosporin. Clinical impr ovement of the bleeding diathesis, a return to normal of the PTT, a de crease in the level of the inhibitor, and a return to normal of the fa ctor VIII level followed use of this drug. We believe that cyclosporin is effective in the treatment of factor VIII inhibitors and deserves further investigation, (C) 1998 Wiley-Liss, Inc.