AIR-POLLUTION AND ALLERGY - EXPERIMENTAL STUDIES ON MODULATION OF ALLERGEN RELEASE FROM POLLEN BY AIR-POLLUTANTS

The fact that allergic diseases increase in prevalence is a generally accepted and worldwide phenomenon. The causes for this increase are no t known: only hypothetical concepts exist. Epidemiological studies com paring Eastern and Western European populations have shown a striking difference in the prevalence of respiratory atopic diseases, which is lower in the East. At the same time, different patterns of air polluti on have been described, namely 'classical' type I, characterized by SO 2 and dust prevailing in the East, and 'modern' type II, characterized by organic compounds, fine particles and ozone, which is more promine nt in the West. Type II was associated in multivariate regression anal ysis with increased prevalence of IgE-mediated allergy. Pollen grains collected from industrial regions with high polyaromatic hydrocarbon l oad in West Germany, but not in East Germany, were shown to be agglome rated with airborne particles. In vitro exposure of pollen to particle s indicated morphological changes and increased allergen release from the pollen. In vitro exposure of pollen to gaseous pollutants (SO2 and NO2) under different conditions of humidity resulted in SO2-induced, but not NO2-induced reduction of allergen release from pollen. It is c oncluded that the bioavailability of grass pollen allergens may be mod ulated by air pollutants, supporting the concept of an interaction bet ween pollen and pollutants in the atmosphere outside the organism whic h in turn may affect allergy-relevant phenomena.