BAEYER-VILLIGER OXIDATION OF THOXY)-7-ANTI-PIPERIDINOBICYCLO[2.2.1]HEPTAN-2-ONE - PROCESS-DEVELOPMENT AND SCALE-UP

Authors
COLEMAN MJ CROOKES DL HILL ML SINGH H MARSHALL DR WALLIS CJ
Citation
Mj. Coleman et al., BAEYER-VILLIGER OXIDATION OF THOXY)-7-ANTI-PIPERIDINOBICYCLO[2.2.1]HEPTAN-2-ONE - PROCESS-DEVELOPMENT AND SCALE-UP, Organic process research & development, 1(1), 1997, pp. 20-25
Citations number
8
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
1
Issue
1
Year of publication
1997
Pages
20 - 25
Database
ISI
SICI code
1083-6160(1997)1:1<20:BOOT>2.0.ZU;2-1
Abstract
The Baeyer-Villiger oxidation of 7-anti-piperidino, 5-endo-biphenyl-4- ylmethoxy substituted norbornan-2-one was developed to provide a robus t, reproducible process for manufacture of the regioisomeric lactone w hich results from migration of the bridgehead carbon atom. Yields of 6 0-63% theory were obtained in a 2250 L plant.