UTILIZATION OF A BENZOYL MIGRATION TO EFFECT AN EXPEDITIOUS SYNTHESISOF THE PACLITAXEL C-13 SIDE-CHAIN

Authors
HU ZY ERHARDT PW
Citation
Zy. Hu et Pw. Erhardt, UTILIZATION OF A BENZOYL MIGRATION TO EFFECT AN EXPEDITIOUS SYNTHESISOF THE PACLITAXEL C-13 SIDE-CHAIN, Organic process research & development, 1(5), 1997, pp. 387-390
Citations number
19
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
1
Issue
5
Year of publication
1997
Pages
387 - 390
Database
ISI
SICI code
1083-6160(1997)1:5<387:UOABMT>2.0.ZU;2-F
Abstract
A benzoyl migration has been used to remove two steps during the asymm etric dihydroxylation literature route to (2R,3S)-N-benzoyl-3-phenylis oserine, the C-13 position side chain of paclitaxel. The modification provides the product as its more desirable methyl ester in similar ove rall yields with no loss of enantiomeric purity when scaled up to mult igram quantities.