ENHANCEMENT OF CDDP CYTOTOXICITY BY CAFFEINE IS CHARACTERIZED BY APOPTOTIC CELL-DEATH

Authors
TAKAHASHI M YAMAMOTO Y HATORI S SHIOZAWA M SUZUKI M RINO Y AMANO T IMADA T
Citation
M. Takahashi et al., ENHANCEMENT OF CDDP CYTOTOXICITY BY CAFFEINE IS CHARACTERIZED BY APOPTOTIC CELL-DEATH, Oncology Reports, 5(1), 1998, pp. 53-56
Citations number
24
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
5
Issue
1
Year of publication
1998
Pages
53 - 56
Database
ISI
SICI code
1021-335X(1998)5:1<53:EOCCBC>2.0.ZU;2-D
Abstract
Through the use of STKM-1 human stomach cancer cells, we investigated the enhancement of the anti-tumor effect and the apoptosis induction o f the CDDP and caffeine combination. Even when the concentration of CD DP was low, CDDP significantly decreased the proliferation of STKM-1 h uman stomach cancer cells, thus confirming the synergistic effect of t he CDDP and caffeine group. The apoptotic labeling index of the CDDP p lus caffeine combination was significantly higher than that of the CDD P group. In conclusion, caffeine enhanced the effect of CDDP by not on ly inhibiting DNA repairs but also inducing apoptosis.