REFLUX ASSOCIATED APNEA IN INFANTS - EVIDENCE FOR A LARYNGEAL CHEMOREFLEX

The mucosa covering the interarytenoid space at the entrance to the la rynx contains specialized nerve endings (receptors) that are stimulate d when a fluid comes into contact with the mucosal surface, These rece ptors mediate several aspiration preventive reflex responses, which in clude swallowing, cessation of breathing, airway constriction or closu re, and coughing. The laryngeal receptors are more sensitive to water than to saline, and therefore the combined reflex response to receptor stimulation is termed the ''laryngeal chemoreflex.'' This reflex can be activated during regurgitation of gastric contents into the pharynx , In which case the several components of the reflex serve to prevent intrapulmonary aspiration of gastric fluid. In certain infants a hyper active laryngeal chemoreflex may cause episodic prolonged apnea, Such reflex-mediated apnea has been implicated in several kinds of prolonge d infantile apnea, including apea of prematurity, gastric regurgitatio n-related apnea, and apnea associated with upper respiratory infection . (C) 1997 by Excerpta Medica, Inc.