S. Dithmar et al., CONFOCAL LASER-SCANNING INDOCYANINE GREEN ANGIOGRAPHY IN PATIENTS WITH CLASSIC CHOROIDAL NEOVASCULARIZATION, Der Ophthalmologe, 94(5), 1997, pp. 343-347
''Classic'' choroidal neovascularization (CNV) has a relatively unifor
m appearance in fluorescein angiography. In contrast, indocyanine gree
n (ICG) angiography shows variable features of well-defined CNV. We ex
amined 31 classic CNV patients secondary to age-related macular degene
ration using a confocal laser scanning ophthalmoscope (Heidelberg Reti
na Angiograph) in order to determine ICG characteristics of classic CN
V. Vascular patterns (97%), a hypofluorescent rim (84%), a hyperfluore
scent margin (42%),late ICG leakage (32%) and ''feeder vessels'' were
identified in variable frequency. Some of the ICG characteristics may
correlate with histological features of the membrane and reflect proli
ferative activity. Extrafoveal ''feeder vessels'' may be amenable to l
aser photocoagulation in the presence of subfoveal CNV.