B. Schmidl et al., LASER FLARE MEASUREMENTS AFTER PHACOEMULS IFICATION AND LENS IMPLANTATION APPLYING 3 DIFFERENT NONSTEROIDAL ANTIINFLAMMATORY DRUGS POSTOPERATIVELY, Der Ophthalmologe, 94(1), 1997, pp. 33-37
In a prospective, randomised, double-masked, parallel-group study we c
ompared the antiinflammatory effect of diclofenac sodium 0.1%, flurbip
rofen 0.03%, and indomethacin 1.0% ophthalmic suspension in 99 patient
s undergoing phacoemulsification and posterior chamber lens implantati
on. The reduction in anterior chamber flare from day 1, as measured wi
th the laser flare-meter (FM-500, KOWA) on day 4-5 postoperatively was
significantly greater in the diclofenac group than with flurbiprofen
(p = 0.022). Patients treated with diclofenac had significantly less b
urning and stinging than patients on flurbiprofen and indomethacin on
postoperative days 4-5 (p < 0.0001) and 12-14 (p = 0.001). Diclofenac
sodium appears to be more potent than flurbiprofen in controlling intr
aocular inflammation after cataract surgery, while having better local
tolerance than flurbiprofen or indomethacin.