Nw. Guldner et al., NEW METHOD FOR MONITORING THE FUNCTIONAL-STATE OF A DYNAMIC CARDIOMYOPLASTY, Journal of thoracic and cardiovascular surgery, 114(6), 1997, pp. 1097-1106
Objective: To assess the impact of a dynamic cardiomyoplasty on failin
g hearts, it is essential to estimate the contraction force of the ske
letal muscle and how its contraction is synchronized with the heart cy
cle. Methods: In a 6-month study a small fluid-filled, balloon-mounted
catheter was placed between the myocardium and the muscular wrap in f
ive adult female Boor goats and two female domestic pigs. The catheter
was connected to a subcutaneous measuring chamber whereby pressure mo
nitoring could be accomplished. Distinct pressure signals as a result
of function of the dynamic cardiomyoplasty and the heart were detected
initially in all animals. Results: Maximal relative pressure from the
dynamic cardiomyoplasty was calculated as 336.2% +/- 69.4% on day 24
+/- 6.1 (n = 7) and end-stage pressure as 59.8% +/- 9.7% on day 174.6
+/- 13.1 (n = 4). A functional loss of pressure signals from the dynam
ic cardiomyoplasty was correlated to severe histologic muscle damage (
n = 3). Pressure signals transferred from the contracting myocardium t
o the catheter showed defined segments of contraction, ejection, and f
illing periods, allowing a mechanical synchronization of the dynamic c
ardiomyoplasty to the heart cycle. Conclusions: This monitoring cathet
er enabled the assessment of the functional state of the dynamic cardi
omyoplasty and allowed a synchronization to the heart cycle. It will p
romote understanding and might help to avoid muscle damage in dynamic
cardiomyoplasty for an improved outcome of the surgical treatment of e
nd-stage heart failure.