ACTIVE EFFLUX BY MULTIDRUG TRANSPORTERS AS ONE OF THE STRATEGIES TO EVADE CHEMOTHERAPY AND NOVEL PRACTICAL IMPLICATIONS OF YEAST PLEIOTROPIC DRUG-RESISTANCE

Mankind is faced by the increasing emergence of resistant pathogens, i ncluding cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focu s on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the poten tiality of this system for further understanding of the mechanism of b road specificity and for development of novel practical applications. (C) 1997 Elsevier Science Inc.