A. Borgeat et al., SPONTANEOUS MOVEMENTS ASSOCIATED WITH ROCURONIUM INJECTION - THE EFFECTS OF PRIOR ADMINISTRATION OF FENTANYL, Journal of clinical anesthesia, 9(8), 1997, pp. 650-652
Study Objective: To determine if prior injection of fentanyl decreases
the incidence of spontaneous movements during rocuronium administrati
on. Design: Prospective, randomized, double-blind, placebo-controlled
study. Setting: University orthopedic surgical center. Patients: 122 A
SA physical status I and II patients scheduled for elective orthopedic
surgery. Interventions: Patients randomly received 2 ug/kg of fentany
l or the equivalent volume of NaCl 0.9% 45 seconds prior to induction
of anesthesia. Induction was performed with propofol 2.5 mg/kg followe
d by rocuronium 0.8 mg/kg 60 seconds later. Spontaneous movements were
scored as follows: a) limited to the hand, b) limited to the elbow, a
nd c) involving the whole arm, including the shoulder. Measurements an
d Main Results: Prior injection of fentanyl (2 ug/kg) significantly de
creased tile incidence of spontaneous movements limited to the hand: 5
% versus 20% (p < 0.05); limited to the elbow: 1 % versus 25% (p < 0.0
5); and involving the whole arm: none versus 12% (p < 0.05). No erythe
ma or any change in the shin surrounding the point of injection of the
involved arm was observed. Twenty-four hours inter, no vein induratio
n was present and no patient complained of any residual pain. Conclusi
on: Prior injection of fentanyl significantly decreases the incidence
of spontaneous movements associated with rocuronium administration. (C
) 1997 by Elsevier Science Inc.