Objective: To compare pregnancy outcomes between morbidly obese and no
nobese women and to determine the effect of gestational weight gain on
pregnancy outcome in morbidly obese women. Methods: A retrospective c
ohort study was conducted comparing 613 morbidly obese and 11,313 nono
bese women who were delivered of a singleton live birth. Morbid obesit
y was defined as a body mass index greater than 35. The incidence of s
elected perinatal and neonatal outcomes was assessed for the two group
s. Multiple logistic regression analysis was used to evaluate the asso
ciation between morbid obesity and various measures of outcome while c
ontrolling for potential confounders. A subanalysis of the morbidly ob
ese patients was performed to assess the effect of gestational weight
gain on pregnancy outcome. Results: Morbidly obese patients were more
likely to experience pregnancy complications including diabetes, hyper
tension, preeclampsia, and arrest-of-labor disorders; however, these w
ere not affected by gestational weight gain. Morbidly obese patients w
ere more likely to experience fetal distress and meconium and to under
go cesarean delivery than their nonobese counterparts (P < .05). Weigh
t gains of more than 25 lb were associated strongly with birth of a la
rge for gestational age (LGA) neonate (P < .01); however, poor weight
gain did not appear to increase the risk of delivery of a low birth we
ight neonate. Conclusion: Gestational weight gain was not associated w
ith adverse perinatal outcome, but it did influence neonatal outcome.
To reduce the risk of delivery of an LGA newborn, the optimal gestatio
nal weight gain for morbidly obese women should not exceed 25 lb.