SYSTEMIC CYCLOSPORINE-A PROPHYLAXIS AFTER KERATOPLASTIES WITH AN ELEVATED RISK FOR IMMUNE-REACTIONS AS THE ONLY ELEVATED RISK FACTOR

Background: In this retrospective study our aim was to evaluate the ef fectiveness of systemic cyclosporin A (CsA) after keratoplasties with an elevated risk for immune reactions as the only elevated risk factor . Patients and methods: Between November 1986 and June 1994, 1121 pene trating keratoplasties, 646 normal-risk and 475 high-risk keratoplasti es were performed. In 130 out of the 475 high-risk keratoplasties an e levated risk for immune reactions was the only elevated risk factor. T wenty-six of these 130 high-risk keratoplasties were treated with syst emic CsA. Results: In the high-risk group keratoplasties with an eleva ted risk for immune reactions as the only elevated risk factor no perm anent graft failure occurred with CsA (100% clear grafts). Without CsA the percentage of clear grafts in this high risk group was only 71.7% according to Kaplan Meier 3 years postoperatively in contrast to 86.0 % in normal-risk keratoplasties. The differences between these three g roups were statistically significant. In the high-risk group keratopla sties with an elevated risk for immune reactions as the only elevated risk factor more immune reactions occured than without CsA or than in normal-risk keratoplasties. However,these immune reactions were mostly of the benign chronic types. Conclusions: Systemic CsA considerably i mproves graft prognosis after high-risk keratoplasties with an elevate d risk for immune reactions as the only elevated risk factor. With CsA application we observed a significant shift from acute to chronic imm une reactions, which respond steroids.